CARDIOVASCULAR
SINGLE CELL RESEARCH LAB
PUBLICATIONS
Dorajoo R, Ihsan MO, Liu W, Lim HY, Angeli V, Park SJ, Chan JM, Lin XY, Ong MS, Muniasamy U, Lee CH, Gurung R, Hee HH, Foo R, Liu J, Kofidis T, Lee CN, Sorokin V. Vascular smooth muscle cells in low SYNTAX scores coronary artery disease exhibit proinflammatory transcripts and proteins correlated with IL1B activation. Atherosclerosis. 2023 Jan 1;365:15-24. DOI | Journal
​
Agarwalla SV, Ellepola K, Sorokin V, Ihsan M, Silikas N, Neto AHC, Seneviratne CJ, Rosa V. Antimicrobial-free graphene nanocoating decreases fungal yeast-to-hyphal switching and maturation of cross-kingdom biofilms containing clinical and antibiotic-resistant bacteria. Biomater Biosyst. 2022 Dec;8:100069. DOI | Journal
Kumar P, Lim A, Poh SL, Hazirah SN, Chua CJH, Sutamam NB, Arkachaisri T, Yeo JG, Kofidis T, Sorokin V, Lam CSP, Richards AM, Albani S. Pro-Inflammatory Derangement of the Immuno-Interactome in Heart Failure. Front Immunol. 2022 Mar 15;13:817514. doi: 10.3389/fimmu.2022.817514. DOI | Journal | PubMed
Park JE, JebaMercy G, Pazhanchamy K, Guo X, Ngan SC, Liou KCK, Lynn SE, Ng SS, Meng W, Lim SC, Leow MK, Richards AM, Pennington DJ, de Kleijn DPV, Sorokin V, Ho HH, McCarthy NE, Sze SK. Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis. Atherosclerosis. 2021 May;324:58-68. DOI | Journal | PubMed
​
​Sorokin V, Vickneson K, Kofidis T, Woo CC, Lin XY, Foo R, Shanahan CM. Role of Vascular Smooth Muscle Cell Plasticity and Interactions in Vessel Wall Inflammation. Front Immunol. 2020 Nov 26;11:599415. DOI | Journal | PubMed | PubMed Central
​
​​Gurung R, Choong AM, Woo CC, Foo R, Sorokin V. Genetic and Epigenetic Mechanisms Underlying Vascular Smooth Muscle Cell Phenotypic Modulation in Abdominal Aortic Aneurysm. Int J Mol Sci. 2020 Aug 31;21(17):6334. DOI | Journal | PubMed | PubMed Central
​
​​Woo CC, Liu W, Lin XY, Dorajoo R, Lee KW, Richards AM, Lee CN, Wongsurawat T, Nookaew I, Sorokin V. The interaction between 30b-5p miRNA and MBNL1 mRNA is involved in vascular smooth muscle cell differentiation in patients with coronary atherosclerosis. Int J Mol Sci. 2019 Dec 18;21(1):11. DOI | Journal | PubMed | PubMed Central
​
​​Derda AA, Woo CC, Wongsurawat T, Richards M, Lee CN, Kofidis T, Kuznetsov VA, Sorokin VA. Gene expression profile analysis of aortic vascular smooth muscle cells reveals upregulation of cadherin genes in myocardial infarction patients. Physiol Genomics. 2018 Aug 1;50(8):648-657. DOI | Journal | PubMed
​
​​de Carvalho LP, Tan SH, Ow GS, Tang Z, Ching J, Kovalik JP, Poh SC, Chin CT, Richards AM, Martinez EC, Troughton RW, Fong AY, Yan BP, Seneviratna A, Sorokin V, Summers SA, Kuznetsov VA, Chan MY. Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction. JACC Basic Transl Sci. 2018 May 30;3(2):163-175. DOI | Journal | PubMed | PubMed Central
​
​​Wongsurawat T, Woo CC, Giannakakis A, Lin XY, Cheow ESH, Lee CN, Richards M, Sze SK, Nookaew I, Kuznetsov VA, Sorokin V. Distinctive molecular signature and activated signaling pathways in aortic smooth muscle cells of patients with myocardial infarction. Atherosclerosis. 2018 Apr;271:237-244. DOI | Journal | PubMed
​
Wongsurawat T, Woo CC, Giannakakis A, Lin XY, Cheow ESH, Lee CN, Richards M, Sze SK, Nookaew I, Kuznetsov VA, Sorokin V. Transcriptome alterations of vascular smooth muscle cells in aortic wall of myocardial infarction patients. Data Brief. 2018 Feb 6;17:1112-1135. DOI | Journal | PubMed | PubMed Central
​
​​​​Cheow ESH, Cheng WC, Yap T, Dutta B, Lee CN, Kleijn DPV, Sorokin V, Sze SK. Myocardial Injury Is Distinguished from Stable Angina by a Set of Candidate Plasma Biomarkers Identified Using iTRAQ/MRM-Based Approach. J Proteome Res. 2018 Jan 5;17(1):499-515. DOI | Journal | PubMed
​
​​Dutta B, Park JE, Kumar S, Hao P, Gallart-Palau X, Serra A, Ren Y, Sorokin V, Lee CN, Ho HH, de Kleijn D, Sze SK. Monocyte adhesion to atherosclerotic matrix proteins is enhanced by Asn-Gly-Arg deamidation. Sci Rep. 2017 Jul 18;7(1):5765. DOI | Journal | PubMed | PubMed Central
​
​​Cheow ES, Cheng WC, Lee CN, de Kleijn D, Sorokin V, Sze SK. Plasma-derived Extracellular Vesicles Contain Predictive Biomarkers and Potential Therapeutic Targets for Myocardial Ischemic (MI) Injury. Mol Cell Proteomics. 2016 Aug;15(8):2628-40. DOI | Journal | PubMed | PubMed Central
​
​Chen YT, Wang J, Wee AS, Yong QW, Tay EL, Woo CC, Sorokin V, Richards AM, Ling LH. Differential MicroRNA Expression Profile in Myxomatous Mitral Valve Prolapse and Fibroelastic Deficiency Valves. Int J Mol Sci. 2016 May 18;17(5):753. DOI | Journal | PubMed | PubMed Central
​
​​Chiong T, Cheow ES, Woo CC, Lin XY, Khin LW, Lee CN, Hartman M, Sze SK, Sorokin VA. Aortic Wall Extracellular Matrix Proteins Correlate with Syntax Score in Patients Undergoing Coronary Artery Bypass Surgery. Open Cardiovasc Med J. 2016 Apr 27;10:48-56. DOI | Journal | PubMed | PubMed Central
​
​​Gijsberts CM, Seneviratna A, de Carvalho LP, den Ruijter HM, Vidanapthirana P, Sorokin V, Stella P, Agostoni P, Asselbergs FW, Richards AM, Low AF, Lee CH, Tan HC, Hoefer IE, Pasterkamp G, de Kleijn DP, Chan MY. Ethnicity Modifies Associations between Cardiovascular Risk Factors and Disease Severity in Parallel Dutch and Singapore Coronary Cohorts. PLoS One. 2015 Jul 6;10(7):e0132278. DOI | Journal | PubMed | PubMed Central
​
​​Sok Hwee Cheow E, Hwan Sim K, de Kleijn D, Neng Lee C, Sorokin V, Sze SK. Simultaneous Enrichment of Plasma Soluble and Extracellular Vesicular Glycoproteins Using Prolonged Ultracentrifugation-Electrostatic Repulsion-hydrophilic Interaction Chromatography (PUC-ERLIC) Approach. Mol Cell Proteomics. 2015 Jun;14(6):1657-71. DOI | Journal | PubMed | PubMed Central
​
​​Li X, Ren Y, Sorokin V, Poh KK, Ho HH, Lee CN, de Kleijn D, Lim SK, Tam JP, Sze SK. Quantitative profiling of the rat heart myoblast secretome reveals differential responses to hypoxia and re-oxygenation stress. J Proteomics. 2014 Feb 26;98:138-49. DOI | Journal | PubMed
​
​​Kong CH, Lin XY, Woo CC, Wong HC, Lee CN, Richards AM, Sorokin VA. Characteristics of aortic wall extracellular matrix in patients with acute myocardial infarction: tissue microarray detection of collagen I, collagen III and elastin levels. Interact Cardiovasc Thorac Surg. 2013 Jan;16(1):11-5. DOI | Journal | PubMed | PubMed Central
​
​​Li X, Arslan F, Ren Y, Adav SS, Poh KK, Sorokin V, Lee CN, de Kleijn D, Lim SK, Sze SK. Metabolic adaptation to a disruption in oxygen supply during myocardial ischemia and reperfusion is underpinned by temporal and quantitative changes in the cardiac proteome. J Proteome Res. 2012 Apr 6;11(4):2331-46. DOI | Journal | PubMed
ABSTRACTS
Ong MS, Heng QQJ, Ihsan MO, Lee CN, Muniasamy U, Lin XY, Sorokin V. Understanding 3D Culture in Smooth Muscle Cell Biology and the Modelling of Atherosclerosis. 90th European Atherosclerosis Society Congress 2022, May 2022, Milan, Italy. Atherosclerosis. 2022 Aug 1;355:16. DOI | Journal
Ihsan MO, Tan DM, Muniasamy U, Ong MS, Lin XY, Lee CN, Dorajoo R, Sorokin V. Muscleblind-Like (MBNL) Protein Family Overexpression Lead to Pro-Synthetic Phenotype Modulation of Arterial Human Vascular Smooth Muscle Cells in Diabetes Mellitus. 90th European Atherosclerosis Society Congress 2022, May 2022, Milan, Italy. Atherosclerosis. 2022 Aug 1;355:205-206. DOI | Journal
Woo CC, Abdul Jalil RB, Lin XY, Lee CN, Sorokin V. Three-dimensional (3D) vascular cell culture model for disease modeling and screening therapies. 88th European Atherosclerosis Society Virtual Congress, Oct 2020. Atherosclerosis. 2020 Dec 1;315:e32. DOI | Journal
Woo CC, Wongsurawat T, Lin XY, Sorokin V. The miRNA 30b-5p targeting mRNA MBNL1 leads to pro-myogenic VSMC phenotype modulation in myocardial infarction patients. 86th European Atherosclerosis Society Congress, May 2018, Lisbon, Portugal. Atherosclerosis. 2018 Aug;275:e46. ​DOI | Journal
Wongsurawat T, Woo CC, Soong R, Sorokin V. Aortic tissue transcriptomic profiling reveal distinct molecular signature of myocardial infarction. Vascular Biology Congress, Oct 2017.
Woo CC, Wongsurawat T, Soong R, Lee CN, Richards M, Kuznetsov V, Sorokin V. Distinctive Pattern of LET-7B and MIR-30B in Human Aortic Smooth Muscle Cells of Myocardial Infarction Patients. ​85th European Atherosclerosis Society Congress, Apr 2017, Prague, Czech Republic. 2017 Aug;263:e63. DOI | Journal
Woo CC, Wongsurawat T, Soong R, Lee CN, Richards M, Kuznetsov V, Sorokin V. Differential Gene Expression and Activation of Signaling Pathway in Aortic Smooth Muscle Cells of Patients with Ischemic Heart Disease. 25th Annual Meeting of Asian Society for Cardiovascular and Thoracic Surgery, Mar 2017, Seoul, Korea.
Woo CC, Tang Z, Chan YS, Lin XY, Soong R, Lee CN, Kuznetsov V, Sorokin V. Patients with unstable angina and myocardial infarction expose remote VSMC phenotype switch and alteration in the proliferation of smooth muscular cell in the aortic wall. 25th Annual World Congress of the World Society of Cardiothoracic Surgeons, Sep 2015, Edinburgh, United Kingdom. J Cardiothorac Surg. 2015 Dec 16;10(Suppl 1):A238. ​DOI | Journal
Woo CC, Leong YS, Tan WL, Tee SG, Chua TS, Aw YB, Chong MS, Cheng YH, Chow CP, Eng CB. An Alternative Way of Storing Specimen in the Freezer. The International Society of Biological and Environmental Repositories 2015 Annual Meeting & Exhibits: Bridging the Canyon – Connecting Biobank Communities through Innovations in Global Health, Research and Environmental Preservation, May 2015, Phoenix, Arizona, United States of America. Biopreserv Biobank. 2015 Jun;13(3):A-1-A-59. DOI | Journal
Carvalho L, Ching JH, Tan SH, Poh SC, Sorokin VA, et al. Sphingolipid Profiling Reveals Ceramides as Prognostic Biomarker in Acute Coronary Syndrome. Singapore Cardiac Society 27th Annual Scientific Meeting, Apr 2015, Singapore.
Chiong T, Cheow ESH, Woo CC, Lin XY, de Kleijn D, Khin LW, Lee CN, Hartman M, Sze SK, Sorokin VA. Syntax Score Correlates with Extracellular Matrix of Aortic Wall in Patients Undergoing Coronary Artery Bypass Surgery. 83rd European Atherosclerosis Society Congress, Mar 2015, Glasgow, United Kingdom. Atherosclerosis. 2015 Jul;241(1):e64. ​DOI | Journal
Chiong T, Cheow ESH, Woo CC, Lin XY, de Kleijn D, Khin LW, Lee CN, Hartman M, Sze SK, Sorokin V. Why SYNTAX score predicts secondary cardiovascular events in patients undergoing coronary intervention. Proteomic analysis of aortic wall patients undergoing coronary artery bypass surgery. National University of Singapore University Surgical Cluster Undergraduate Research Week, Oct 2014, Singapore.
Sorokin V, Woo CC, Lin XY, Kofidis T, Lee CN. Role of Micro RNA in Arterial Wall Remodeling in Patients with Advanced Coronary Artery Disease Undergoing Bypass. 22nd Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery, Apr 2014, Istanbul, Turkey.
Sze SK, de Kleijn D, Sorokin V, Lee CN. Protein Deamidation in Cardiovascular Disease. 23rd American Peptide Symposium / 6th International Peptide Symposium, Jun 2013, Hawaii, United States of America. Biopolymers. 2013 May;100(3):311.
​
Woo CC, Kong CH, Chan YS, Wong C, Leong JJ, Lee CN, Sorokin V. Reliable Procedure to Maintain RNA Quality During Laser Capture Microdissection of Human Aortic Smooth Muscle Cells. 60th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Aug 2012, Brisbane, Australia. Heart Lung Circ. 2012 Aug;21(S1):S271. ​DOI | Journal
Kong CH, Lin XY, Woo CC, Lee CN, Richards M, Wong HC, Sorokin V. Characteristics of Aortic Wall Extracellular Matrix in Patients with Acute Myocardial Infarction: Tissue Microarray Detection of Collagen I, Collagen III and Elastin Levels. 60th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Aug 2012, Brisbane, Australia. Heart Lung Circ. 2012 Aug;21(S1):S32. DOI | Journal
Lin XY, Eng CB, Singh R, Woo CC, Sorokin V. Optimization of Tissue Collection Workflow Helps to Reduce Ischemia Time. International Society for Biological and Environmental Repositories 2011 Annual Meeting & Exhibits: Impact and Public Benefits of Biorepositories, May 2011, Arlington, Virginia, United States of America. Biopreserv Biobank. 2011 Apr;9(1):72-114. DOI | Journal
​
Sorokin V, Eng CB, Singh R, Lin XY, Kofidis T, Tan C, Caleb M, Lee CN. Cardio-vascular Tissue Bank Project. Tissue Reinforcement for Translational Research in Cardiovascular Disease. 6th Asian Interventional Cardiovascular Therapeutics Congress, Jul 2010, Singapore.